Here's a set screw tip. Use 2 shorter ones. Install the first then grind the tip of the second flat and install on top of the first. the reason for grinding it flat is so as to not mess up the head of the first with the cup point of the second.
We've been doing this for years and never had ANY come loose and no loctite. We have some setups with 2 1/8" set screws on top of each other rather than 1 1/4" long one with loctite.
Just snug up the first one and tighten the second one a bit more than the first.
This is a standard practice in assembling Bridgeport mills from the factory...not my invention, but it sure works.
You should also have set screws at 2 locations on the pulley...traditionally 90 degrees from each other..but that is open to debate...some like 60 and I often drill thru for 180 locations....keeps things balanced at higher r's.
As an alternative, hollow set screws can be also used as a lock over another regular set screw.
Please feel free to add, comment or ask questions as you see fit.
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